Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-25 @ 12:39 AM
Ignite Modification Date:
2025-12-25 @ 12:39 AM
NCT ID:
NCT01504867
Eligibility Criteria:
Inclusion Criteria:
* Adult patients (age \> 18) admitted to the hospital through the emergency department (ED)
* At high risk of developing acute lung injury (ALI) Lung Injury Prediction Score (LIPS) greater than or equal to 4
Exclusion Criteria:
* Anti-platelet therapy on admission or within 7 days prior to admission
* Presented to outside hospital ED \> 12 hrs before arrival at site's facility
* Inability to obtain consent within 12 hours of hospital presentation
* Admitted for elective surgery
* Acute lung injury prior to randomization
* Receiving mechanical ventilation through a tracheostomy tube prior to current hospital admission (patient who is ventilator dependent)
* Presence of bilateral pulmonary infiltrates on admission if he or she has a history of bilateral pulmonary infiltrates (as evidenced by previous x-rays) that can reasonably explain the current degree of pulmonary infiltrates present.
* Presentation due to pure heart failure and no other known risk factors for ALI.
* Allergy to aspirin or non steroidal anti inflammatory drugs (NSAIDs)
* Bleeding disorder
* Suspected active bleeding or judged to be at high risk for bleeding
* Active peptic ulcer disease (within past 6 months)
* Severe chronic liver disease
* Inability to administer the study drug
* Expected hospital stay \< 48 hours
* Admitted for comfort or hospice care
* Patient, surrogate or physician not committed to full support. (Exception: a patient will not be excluded if he/she would receive all supportive care except for attempts at resuscitation from cardiac arrest)
* Not anticipated to survive \> 48 hours
* Previously enrolled in this trial
* Enrolled in a concomitant intervention trial
* Pregnant or breastfeeding
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Study:
NCT01504867
Study Brief:
Protocol Section:
NCT01504867