Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-25 @ 12:39 AM
Ignite Modification Date:
2025-12-25 @ 12:39 AM
NCT ID:
NCT02742467
Eligibility Criteria:
Inclusion Criteria:
* Patients with Sitting SBP ≥140 mm Hg and \< 160 mmHg on one antihypertensive agen or
* Sitting SBP ≥ 150 mm Hg and \< 180 mm Hg on no antihypertensive treatment.
Exclusion Criteria:
* Congestive heart failure (clinically defined).
* Serum creatinine levels greater than 170 µmol/l or estimated glomerular filtration rate (eGFR) \< 30 ml/min.
* History of coronary heart disease (i.e., chronic stable angina, myocardial infarction or acute coronary syndrome).
* History of a stroke or other cerebrovascular accident (i.e. transient ischaemic attack or reversible ischaemic neurological deficit).
* Known or suspected secondary hypertension.
* Any other concomitant illness, physical or mental impairment that could interfere with the effective conduct of the study.
* Pregnancy or those of child-bearing age who are not taking reliable contraception.
* Patients with a history of intolerance to any of the study medications for example angioedema or dry cough with angiotensin converting enzyme inhibitors.
* Patients on maximum dose of any of the study medications as monotherapy (i.e. amlodipine 10 mg/day or hydrochlorothiazide 25 mg/day or perindopril 8 mg/day)
* Gout.
* Serum potassium \< 3.5mmol/L at screening.
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
30 Years
Maximum Age:
79 Years
Study:
NCT02742467
Study Brief:
Protocol Section:
NCT02742467