Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-25 @ 12:36 AM
Ignite Modification Date:
2025-12-25 @ 12:36 AM
NCT ID:
NCT02253667
Eligibility Criteria:
Inclusion Criteria:
* Consecutive patients who had end-stage lung disease (lung cancer, pulmonary fibrosis, COPD, …) - (McCabe score \> 3 \[\<6 months life expectancy\] and a Palliative Prognostic Index score ≥ 4) admitted to hospital because of acute respiratory failure and distress
* Had chosen to forego all life support and receiving only palliative care
* Severe hypoxemia (PaO2/FiO2\< 250)
* At least one of the following: dyspnoea (Borg scale ≥4), signs of respiratory distress, and respiratory rate greater than 30 beats per min
Exclusion Criteria:
* Patients had to be competent (Kelly score \<4)
* Refusal of treatment
* Weak cough reflex
* Agitation or non-cooperation
* Uncontrolled cardiac ischemia or arrhythmias
* Failure of more than two organs
* Use of opioids within the past 2 weeks
* Adverse reactions to opioids
* History of substance misuse
* Known contraindication for morphine (acute renal failure and recent head injury)
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
21 Years
Study:
NCT02253667
Study Brief:
Protocol Section:
NCT02253667