Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-25 @ 12:33 AM
Ignite Modification Date:
2025-12-25 @ 12:33 AM
NCT ID:
NCT02525367
Eligibility Criteria:
Inclusion Criteria:
General criteria:
* Patients have (access to) a computer with access to the Internet. Patients are capable of using a keyboard and computer mouse.
* Patients are willing to sign informed consent.
PD-specific criteria:
* A compilation score of executive functions (i.e. Stroop, Trail Making Task, Fluency) shows deficit, which lies between 1 and 2 standard deviation (SD) below the mean of healthy Dutch norm population.
* Patients are diagnosed with Parkinson's disease according to the United Kingdom Parkinson's Disease Society Brain Bank criteria.
* Patients are in Hoehn \& Yahr stadium \< 4, and are medically stable during a month prior to the intervention. The medication will be attempted to remain stable for the remainder of the intervention.
* Patients are 50 to 70 years old.
MS-specific criteria:
* A compilation score of episodic memory (i.e. Rey Auditory Verbal Learning Test, Location Learning Test) shows deficit, which lies between 1 and 2 SD below the mean of healthy norm population.
* Patients have been diagnosed with MS for a period longer than three month prior to inclusion in this study according to the renewed McDonald criteria.
* Patients have been on stable medication for at least three months.
* Patients are 30 to 45 years old.
PostECT-specific criteria:
* Unipolar depressive patients indicated for ECT, who experience cognitive complaints after treatment with ECT.
* Patients have undergone the full ECT-procedure.
* Phonemic fluency and autobiographical memory (measured by the Kopelman Autobiographical Interview) show deficit: significant individual deterioration is present (\> 1.5 SD deterioration), accounting for test- retest effects.
* Patients are 50 to 70 years old.
Exclusion Criteria:
General criteria:
* Indications for presence of dementia.
* Presence of traumatic brain injury.
* A psychiatric disorder (in the postECT group: other than unipolar depression).
* No history or presence of drug or alcohol abuse.
* Inability to undergo a neuropsychological assessment (e.g. due to fast fatigue, seeing problems or language barrier).
PD-specific criteria:
\- Psychotic symptoms, as screened by the Questionnaire for Psychotic Experiences (QPE). Benign hallucinations with insight are not contraindicated).
MS-specific criteria:
\- Patients with MS can't have relapses or can't use corticosteroids 4 weeks prior to the start of the study.
postECT-specific criteria:
\- Indications for presence of delirium.
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
30 Years
Maximum Age:
70 Years
Study:
NCT02525367
Study Brief:
Protocol Section:
NCT02525367