Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-25 @ 12:32 AM
Ignite Modification Date:
2025-12-25 @ 12:32 AM
NCT ID:
NCT00182767
Eligibility Criteria:
Inclusion Criteria:
* Histologically or cytologically confirmed diagnosis of 1 of the following: advanced ovarian epithelial, primary peritoneal cavity, or fallopian tube cancer (phase I and II) or metastatic breast cancer (phase I only).
* Platinum- and taxane-resistant disease, defined as a disease-free interval of \< 6 months after completion of platinum- and taxane-based chemotherapy. Disease progression during the regimen (phase II) or previously treated with \>= 2 prior regimens for metastatic breast cancer, including 1 taxane-based regimen in the adjuvant or metastatic setting (phase I).
* Meets 1 of the following criteria: Previously treated with a standard course of taxane- and platinum-based chemotherapy for ovarian epithelial, primary peritoneal cavity, or fallopian tube cancer, that is platinum-refractory or -sensitive disease (phase I );
* Measurable or evaluable disease, meeting 1 of the following criteria: unidimensionally measurable lesion, known disease and CA 125 \> 50 U/mL on 2 occasions \>= 1 week apart or known disease and CA 27-29, CA 15-3, or CA 125 \> 50 U/mL on 2 occasions \>= 1 week apart (for breast cancer patients)
* ECOG 0-2 or Karnofsky 60-100%
* At least 3 weeks since prior chemotherapy (6 weeks for nitrosoureas or mitomycin) and recovered.
* At least 1 week since prior chemotherapy if given on a daily or weekly schedule and recovered.
* At least 3 weeks since prior radiotherapy and recovered.
* Recovered for more than 4 weeks from all adverse events related to prior agents.
* Normal organ function including:
* Normal bilirubin
* WBC \>= 3,000/mm3
* Absolute neutrophil count \>= 1,500/mm3
* Platelet count \>= 100,000/mm3
* AST and ALT =\< 2.5 times upper limit of normal (ULN)
* Creatinine =\< 1.5 times ULN or Creatinine clearance ≥ 60 mL/min
Exclusion criteria:
* No other concurrent investigational agents.
* No concurrent combination antiretroviral therapy for HIV-positive patients.
* No other concurrent anticancer therapy.
* Has received a previous chemotherapy regimen for this cancer that included drugs such as docetaxel or paclitaxel.
* Life expectancy of more than 3 months
* No symptomatic congestive heart failure
* No unstable angina pectoris
* No cardiac arrhythmia
* Not pregnant or nursing
* Fertile patients must use effective contraception
* No history of allergic reaction attributed to compounds of similar chemical or biological composition to Cremophor® or study drugs
* No neuropathy \>= grade 2
* No ongoing or active infection
* No psychiatric illness or social situation that would preclude study compliance.
* No other uncontrolled illness.
* No active brain metastases, including any of the following: evidence of cerebral edema by CT scan or MRI, evidence of disease progression on prior imaging studies, requirement for steroids or clinical symptoms of brain metastasis.
Healthy Volunteers:
False
Sex:
FEMALE
Minimum Age:
18 Years
Study:
NCT00182767
Study Brief:
Protocol Section:
NCT00182767