Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-25 @ 12:32 AM
Ignite Modification Date:
2025-12-25 @ 12:32 AM
NCT ID:
NCT00486967
Eligibility Criteria:
Inclusion Criteria:
* One hundred patients with Left ventricular Ejection Friction (LVEF) \<35% in NYHA class I II III or IV; aged 30-90, attending the CHF clinic will be studied
* Diagnosis of CHF will be based on medical history of exertional dyspneoa, muscle fatigue and/or fluid retention and diminished LVEF (LVEF\<35%)
* The diagnosis of ischemic heart disease will be based on documentation of previous myocardial infarction, coronary artery bypass surgery or pathologic findings on coronary angiography. Idiopathic dilated cardiomyopathy will be diagnosed in the absence of a specific etiology for left ventricular dysfunction and on the basis of normal coronary arteries
* All patients should be stable with their treatment and no change in their treatment regimen for \> 6 weeks before the study
* Patients with CHF due to coronary artery disease are more likely to have abnormalities in glucose metabolism than are patients with CHF due to idiopathic dilated cardiomyopathy. Therefore, we also plan to study a control group \[n=50\] of age and sex and BMI matched patients divided into 2 groups 25 with coronary artery disease without heart failure and 25 healthy control. These patients will be identified from the Cardiology Clinics
Exclusion Criteria:
* Patients with decompensated CHF with signs of congestion
* Since the objective of the study is to assess prevalence of insulin resistance in CHF and not CHF secondary to other diseases like diabetes mellitus (DM), patients suffering from DM will be excluded
* Individual found during study cognitively impaired rendering them incapable to take part
Healthy Volunteers:
True
Sex:
ALL
Minimum Age:
30 Years
Maximum Age:
90 Years
Study:
NCT00486967
Study Brief:
Protocol Section:
NCT00486967