Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-25 @ 12:31 AM
Ignite Modification Date:
2025-12-25 @ 12:31 AM
NCT ID:
NCT00208767
Eligibility Criteria:
Inclusion Criteria:
* \> 0.65 mm intima-media thickness of the carotid artery measured by ultrasound
* Males aged 21-80 years or women without child bearing potential up to age 80
* Can be on concomitant therapy with aspirin, thiazide diuretics, calcium antagonists (for treatment of hypertension), or beta-receptor antagonists.
* May be on statin if on stable dose for at least 2 months before recruitment
Exclusion Criteria:
* Angiotensin-converting enzyme (ACE) inhibitor or ARB therapy in the previous 3 months.
* Initiation or change in dose of statin therapy within 2 months before the study
* Inability to return to Emory for follow-up blood drawing and MR imaging
* Age \< 21 or \> 80 years
* Premenopausal females with potential for pregnancy
* Current neoplasm
* Chronic renal failure \[creatinine \> 2.5 mg/dL\]
* Diabetes with hemoglobin (Hb) A1c \> 8.5
* Anticipated change in lipid lowering therapy
* Inability to give informed consent
* MR exclusion criteria
* Blood pressure \> 140 mmHg systolic and \> 90 mmHg diastolic
* Low-density lipoprotein (LDL) cholesterol level \>130 mg/dl
* Acute coronary syndrome within 2 months
* Acute cerebrovascular accident within 2 months
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
21 Years
Maximum Age:
80 Years
Study:
NCT00208767
Study Brief:
Protocol Section:
NCT00208767