Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-25 @ 12:31 AM
Ignite Modification Date:
2025-12-25 @ 12:31 AM
NCT ID:
NCT05849467
Eligibility Criteria:
* INCLUSION CRITERIA:
In order to be eligible to participate in this study, an individual must meet all of the following criteria:
Multiple Sclerosis Inclusion Criteria
* Enrolled in the NINDS Natural History Study for MS (protocol 89-N-0045)
* Able to understand, and willing to sign, a written, informed consent document.
* Willing to comply with all study procedures and available for the duration of the study.
* Male or female, aged \>=18.
* Diagnosis of MS according to the 2017 revision of the McDonald diagnostic criteria48 (in the presence or absence of a clinical relapse).
PML Inclusion Criteria
* Enrolled in the NINDS Natural History Study for PML (protocol 13-N-0017)
* Able to understand and willing to sign a written, informed consent document
* Willing to comply with all study procedures and available for the duration of the study.
* Male or female, aged \>=18.
* Diagnosis of definite PML according to 2013 AAN Consensus Criteria49 or PML-IRIS based on clinical, radiological and laboratory evidence.
Patients with Known or Suspected Neuroinflammatory Diseases and Evidence of Open BBB Inclusion Criteria
* Clinical evaluation suggesting an inflammatory disorder of the central nervous system other than MS or PML.
* Recent brain MRI (within 1 month) with gadolinium enhancement indicating open BBB.
* Able to understand and willing to sign a written, informed consent document.
* Willing to comply with all study procedures and available for the duration of the study.
* Male or female, aged \>=18.
EXCLUSION CRITERIA:
An individual who meets any of the following criteria will be excluded from participation in this study:
* Pregnant or lactating.
* Contraindications for MRI gadolinium contrast administration or 3T MRI.
* History of, or current diagnosis with, concomitant medical or clinical conditions that would adversely affect participation in this study.
* Weighs \> 350 lb (158 kg; weight limit for the scanner table) or is unable to fit within the MRI or PET imaging gantry.
* Severe claustrophobia unresponsive to oral anxiolytics.
* Has an alkaline phosphatase level greater than 2x ULN (unless known to have non-liver related disorder) OR AST greater than 1.5 x ULN OR ALT greater than 1.5 x ULN.
* Has a total bilirubin \>1.5X ULN, unless known to have elevated bilirubin due to nonliver related disorder or Gilbert s.
* Creatinine clearance \< 60 mL/min as estimated by the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI)
* For females of reproductive potential: inability to use highly effective contraception for at least one month prior to screening and during study participation.
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Maximum Age:
120 Years
Study:
NCT05849467
Study Brief:
Protocol Section:
NCT05849467