Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-25 @ 12:24 AM
Ignite Modification Date:
2025-12-25 @ 12:24 AM
NCT ID:
NCT01057758
Eligibility Criteria:
Inclusion Criteria:
* Duration of mechanical ventilation \> 48 h
* First episode of suspicion of VAP with a Clinical Pulmonary Infection Score modified ≥ 5
* BAL, plugged telescopic catheter and/or tracheal aspirates quantitative cultures performed prior administration of antibiotics
* Informed consent
Exclusion Criteria:
* Statin treatment received under mechanical ventilation
* Age less than 18 years
* Pregnancy
* Unable to receive or unlikely to absorb enteral study drug
* Patient, surrogate, or physician not committed to full support ).
* Moribund patient with a SAPS II score \> 75
* Simvastatin specific exclusions Allergy or intolerance to statins Physician insistence for the use or avoidance of statins during the current hospitalization CK , ALT or AST \> 5 times the upper limit of normal Receiving cyclosporine, gemfibrozil, lopinavir, ritonavir itraconazole, kétoconazole, érythromycine, clarithromycine, télithromycine, néfazodone, verapamil, diltiazem
* Severe chronic liver disease
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Study:
NCT01057758
Study Brief:
Protocol Section:
NCT01057758