Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-25 @ 12:22 AM
Ignite Modification Date:
2025-12-25 @ 12:22 AM
NCT ID:
NCT03889158
Eligibility Criteria:
Inclusion Criteria:
* Males and females willing to provide informed consent
* 18-35 or 55-75 years of age
* Non-smoker
* No use of anti-inflammatory medication within last 2 weeks
* Aerobically trained (defined as performing aerobic exercise on ≥4 days/week, for ≥30 minutes, for at least the past 3 months AND a VO2max ≥75th age- and sex-specific percentile according to ACSM)
* /// OR /// Sedentary (defined as being involved in less than 30 minutes of moderately-intense physical activity per day, \< 3 days/week AND a VO2max ≤ 50th age- and sex-specific percentile according to ACSM)
Exclusion Criteria:
* Body mass index \>35 kg/m2
* Pregnancy, hormone replacement therapy, or peri-menopausal
* Known cardiovascular (i.e. atherosclerosis, uncontrolled hypertension, stroke, myocardial infarction, etc.), inflammatory (i.e. Crohn's disease, arthritis, etc.), or metabolic (i.e. Diabetes mellitus) disease
* Medications known to influence cardiovascular outcomes (i.e. heart rate, blood pressure, endothelial function, etc)
* Regular use of medications to reduce inflammation (NSAIDS, aspirin, steroids, etc)
* Bleeding disorders
* Illness, other vaccination, or antioxidant use within 2 weeks prior to screening
* Typhoid vaccination within previous 2 years or prior adverse reaction
* VO2max in 51st - 74th age- and sex-specific percentile according to ACSM (measured during first testing visit)
* Non-English speaking participants
Healthy Volunteers:
True
Sex:
ALL
Minimum Age:
18 Years
Maximum Age:
75 Years
Study:
NCT03889158
Study Brief:
Protocol Section:
NCT03889158