Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-25 @ 12:21 AM
Ignite Modification Date:
2025-12-25 @ 12:21 AM
NCT ID:
NCT05256758
Eligibility Criteria:
Inclusion Criteria:
* Asymptomatic moderate to severe AS (with at least two of the following: aortic valve area \<1.5 cm2, peak pressure gradient \>36 mmHg or mean pressure gradient \>25 mmHg)
* Not planned aortic valve replacement or transcatheter aortic valve implantation (TAVI)
* Age \>18
* No other significant valvular pathology
* No contraindication to magnetic resonance imaging.
Exclusion Criteria:
* Known coronary artery disease, history of angina, myocardial infarction or presence of regional wall motion abnormalities
* Other underlying cardiomyopathy
* Left ventricular ejection fraction\<50%
* Uncontrolled hypertension
* Diabetes Mellitus
* Liver impairment
* Pregnancy and lactation
* Body mass index \>35 kg/m2
* Renal impairment (eGFR\<30 ml/min)
* Intolerance to or concurrent use of fibrates or PPARĪ± agonists.
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Study:
NCT05256758
Study Brief:
Protocol Section:
NCT05256758