Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-25 @ 12:12 AM
Ignite Modification Date:
2025-12-25 @ 12:12 AM
NCT ID:
NCT03846258
Eligibility Criteria:
Inclusion Criteria
* Adult patients (≥ 18 years of age)
* Ability to obtain informed consent, either from patient or legally authorized representative (LAR)
* Diagnosis of AKI according to KDIGO definition \[an increase in serum creatinine concentration of greater than or equal to 0.3 mg/dL within the first 48 hours of injury, a relative increase in serum creatinine of greater than or equal to 50% (1.5-fold from baseline) within the first 7 days of injury, or a reduction in urine output (\<0.5 mL/kg/h for more than 6 hours)\]
* CRRT initiated for the first time during current ICU admission.
* Bicarbonate ≤ 22 mEq/L
* Arterial pH between 7.05 and 7.25(if an ABG is not available, venous pH must be between 7.00 and 7.20)
Exclusion Criteria
* Pregnancy (women of child-bearing potential must have a negative pregnancy test)
* Diagnosis of End-Stage renal disease and receiving Hemodialysis or peritoneal dialysis prior to ICU admission (this information will be easily obtained by the nephrology team)
* Arterial pH \<7.05 or \>7.25 (if an ABG is not available, Venous pH \<7.00 or \>7.20)
* Potassium level \>6.0 mmol/L
* Severe acute liver failure meeting all the following criteria):
* INR \>2
* AST/ALT more than 500 U/L and
* Bilirubin more than 12 mg/dL)
* Previous enrollment in this study
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Maximum Age:
100 Years
Study:
NCT03846258
Study Brief:
Protocol Section:
NCT03846258