Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-25 @ 12:12 AM
Ignite Modification Date:
2025-12-25 @ 12:12 AM
NCT ID:
NCT00792558
Eligibility Criteria:
Inclusion Criteria:
* Confirmed diagnosis of advanced non-hematologic malignancy. Dose expansion cohort restricted to subjects with advanced or metastatic gastroesophageal cancer, squamous cell cancers of the head and neck, and castration resistant prostate cancer
* ECOG status 0-1
Exclusion Criteria:
* WOCBP unwilling/unable to use acceptable contraception methods, and women pregnant or breast feeding
* Symptomatic brain metastasis
* Uncontrolled or significant cardiovascular disease
* History of thromboembolic events or bleeding diathesis in past 6 months
* Conditions requiring prophylactic anticoagulation or chronic anti-platelet therapy
* Serious non-healing wounds, ulcers or bone fractures in past 3 months
* Hemorrhage or bleeding event \>= CTCAE grade 3 in past 4 weeks
* Proteinuria \>= 2+ on dipstick or \>= 1gm/24 hours
* Concurrent chemotherapy, hormonal therapy, immunotherapy, radiation therapy or therapy with any other investigational product
* Concurrent herbal, alternative, food supplements, or strong CYP 3A4 inhibitors or inducers
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Study:
NCT00792558
Study Brief:
Protocol Section:
NCT00792558