Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-25 @ 12:02 AM
Ignite Modification Date:
2025-12-25 @ 12:02 AM
NCT ID:
NCT00376558
Eligibility Criteria:
Inclusion Criteria:
* Males or females between 21 and 45 years old
* Fulfill DSMIV criteria for cocaine abuse or dependence
* Able to give informed consent and comply with study procedures
* Medically Healthy
Exclusion Criteria:
* Major DSM-IV Axis I disorder other than cocaine abuse or dependence. Subjects with a history of other psychostimulant abuse/dependence or compulsive gambling will be excluded.
* Current use of opiates, sedative-hypnotic, and/or cannabis more than twice a week (use less than twice a week is acceptable).
* Current use of psychotropic medication such as antipsychotics or antidepressants.
* Presence or positive history of severe medical or neurological illness (including epilepsy), or any cardiovascular disease, low hemoglobin (Hb \< 14 gm/dL in males, Hb \< 12 gm/dL in females), or SGOT or SGPT \> 2-3 times normal. Chronic active hepatitis B or C will also be an exclusion criteria.
* Resting SBP \>150, DBP \> 90
* Pregnancy or lactation, lack of effective birth control during 15 days before the scans\*
* Evidence /report of any heart abnormality during intake medical history, EKG or physical exam.
* Metal implants or paramagnetic objects contained within the body which may interfere with the MRI scan, as determined in consultation with a neuroradiologist and according to the guidelines set forth in the following reference book commonly used by neuroradiologists: "Guide to MR procedures and metallic objects" Shellock, PhD, Lippincott Williams and Wilkins, NY 2001.
* Lifetime exposure to radiation in the workplace, or history of participation in nuclear medicine procedures, including research protocols \*\*
* Positive Allen Test indicating lack of collateral blood flow to hand
* History of sensitivity to methylphenidate
Healthy Volunteers:
True
Sex:
ALL
Minimum Age:
21 Years
Maximum Age:
45 Years
Study:
NCT00376558
Study Brief:
Protocol Section:
NCT00376558