Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-25 @ 12:01 AM
Ignite Modification Date:
2025-12-25 @ 12:01 AM
NCT ID:
NCT03170258
Eligibility Criteria:
Inclusion Criteria:
1. 18-45 years of age
2. Right handed
3. In good general health
4. Male or Female
5. For ND individuals: Self-reported smoking ≥ 5 combustible cigarettes per day
6. For ND individuals: Afternoon expired CO concentration of ≥ 8 ppm
7. For ND individuals: Is willing and able to abstain from smoking for a few hours
Exclusion Criteria:
1. History of chronic/significant medical condition
2. Current or past 6 month use of prescription medications for psychiatric conditions (e.g., depression, anxiety)
3. Current or past 6 month diagnosis of anxiety, bipolar disorder, depression, OCD, schizophrenia, psychosis, or personality disorder.
4. Current substance abuse or dependence or history within the last 6 months (other than nicotine for ND individuals)
5. For ND individuals: Positive drug test for anything other than marijuana
6. For ND individuals: Currently on nicotine replacement therapy
7. For ND individuals: Individuals who role their own cigarettes
8. For ND individuals: Daily cannabis use
9. For ND individuals: Consume more than 21 alcoholic drinks per week
10. For ND individuals: Use harder drugs (e.g., cocaine, methamphetamine) more than 10 times per year
11. For ND individuals: Currently taking medication that directly acts on the dopamine system (e.g., L-DOPA).
12. Inability to understand written and/or spoken English language
13. For MRI subjects: Claustrophobia or other contraindications to MRI scanning
14. For MRI subjects: If female, pregnancy as determined by urine pregnancy test on the day of MRI scanning
15. For MRI subjects: Presence of any metal in the body (e.g., implant, non-removable piercing, metal IUD)
16. For MRI subjects: Head injury resulting in loss of consciousness
17. For MRI subjects: Worked with metal (e.g., welding) or had an injury to the eye involving metal
18. For MRI subjects: Weigh more than 250 pounds
Healthy Volunteers:
True
Sex:
ALL
Minimum Age:
18 Years
Maximum Age:
45 Years
Study:
NCT03170258
Study Brief:
Protocol Section:
NCT03170258