Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 11:52 PM
Ignite Modification Date:
2025-12-24 @ 11:52 PM
NCT ID:
NCT01469351
Eligibility Criteria:
Inclusion Criteria:
* Informed consent before study-related activity
* Adult competent persons
* Diagnosed with diagnosed Alzheimer's disease. With a MMSE score between 18-21 the diagnosis should be entirely based on the clinic, while diagnosis by MMSE with a score \> 22 should be diagnosed by spinal puncture
* Age ≥ 50 years and ≤ 80 years
* Caucasians
Exclusion Criteria:
* Diabetes mellitus
* Clinically significant liver (s-ALT \> 2 times upper reference or creatinine-clearance \< 30 mL / min, assessed on Cockcroft-Gault normogram)
* Clinically significant anemia
* Other clinically relevant abnormal biochemical value
* Current or former presence of one of the following diseases with clinical relevance:
1. another CNS-illness other than diagnosed depression treated with SSRI or SSRI similar drugs.
2. liver disease
3. kidney disease
4. endocrinological disease other than well controlled hypothyroidism
* Current or history of chronic or acute pancreatitis
* Any disease which the investigators believe may affect the study
* Patients treated with TCA or neuroleptics
* Known abuse of alcohol or drugs
* Known allergy to liraglutide or any of the other components (disodium phosphate dihydrate, propylene glycol and phenol)
* Participation in a clinical trial less than 3 months before inclusion in this study
* Persons who within a period of the last 2 years have participated in scientific experiments involving the use of isotopes, or who have had greater diagnostic tests performed using applied ionizing radiation
* If patients are treated with SSRI or SSRI similar drugs or antihypertensives this treatment should be stable
* Claustrophobia or other missing cooperation
* Severe overweight \> 130kg
* Ferro-magnetic prosthesis, pacemaker or other metals incorporated in the body
* Significant abnormities in the brain detected by MR scanning
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
50 Years
Maximum Age:
80 Years
Study:
NCT01469351
Study Brief:
Protocol Section:
NCT01469351