Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 1:48 PM
Ignite Modification Date:
2025-12-24 @ 1:48 PM
NCT ID:
NCT03866395
Eligibility Criteria:
Inclusion Criteria:
* coronary artery disease with chronic stable angina for more than three months (Canadian Cardiovascular Society-CCS-class I-III);
* percutaneous revascularization with stent implantation at least one;
* signs/symptoms of residual ischemia; sinus rhythm; HR ≥ 70 bpm at rest;
* ability to perform an echocardiogram stress test with the tilting bicycle stress test (BST);
* good acoustic window;
* age ≥ 18 years.
Exclusion Criteria:
* drugs intolerance or hypersensitivity
* EF ≤ 40 %
* NYHA class III to IV;
* CCS IV
* atrial fibrillation or flutter
* presence of a pacemaker or implantable defibrillator
* II or III degree AV block
* HR ≤ 70 bpm at rest or sick sinus syndrome
* any condition that could interfere with the ability to exercise stress test like Wolff- Parkinson-White syndrome, left bundle branch block, left ventricular hypertrophy;
* rate-corrected QT interval (QTc) greater than 500 ms or the use of drugs that prolong the QTc interval
* symptomatic hypotension or uncontrolled hypertension (systolic blood pressure at rest ≥ 180 mmHg or diastolic blood pressure ≥ 100 mmHg)
* severe liver disease and severe renal impairment (creatinine clearance ≤ 30 ml/min)
* electrolyte disorders
* uncontrolled thyroid disease
* pregnancy.
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Maximum Age:
75 Years
Study:
NCT03866395
Study Brief:
Protocol Section:
NCT03866395