Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 1:41 PM
Ignite Modification Date:
2025-12-24 @ 1:41 PM
NCT ID:
NCT04329195
Eligibility Criteria:
Inclusion Criteria:
* Age ≥ 18 years old.
* Chronically treated with RAS blockers (ACE inhibitors or ARBs on the last prescription prior to admission with a treatment duration ≥ 1 month).
* Diagnosis of COVID-19 confirmed by the presence of SARS-CoV-2 on any biological sample with any detection method.
* Patients hospitalized in a non-intensive care unit.
* Pregnancy test at inclusion visit for women of childbearing potential.
* Women of childbearing potential must agree to use adequate contraception according to recommendations related to contraception and pregnancy testing in clinical trials, by Clinical Trial Facilitation Group (CTFG).
Exclusion Criteria:
* Shock requiring vasoactive agents.
* Acute respiratory distress syndrome requiring invasive mechanical ventilation.
* Circulatory assistance.
* History of malignant hypertension according to the definition of the 2018 ESC/ESH guidelines on hypertension.
* Uncontrolled blood pressure despite the use of five antihypertensive drugs.
* History of nephrotic syndrome.
* History of hospitalization for hemorrhagic stroke in the past 3 months.
* RAS blockers therapy previously stopped \> 48h.
* No affiliation to the French Health Care System "Sécurité Sociale".
* Inability to obtain informed consent.
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Study:
NCT04329195
Study Brief:
Protocol Section:
NCT04329195