Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 11:39 PM
Ignite Modification Date:
2025-12-24 @ 11:39 PM
NCT ID:
NCT03262051
Eligibility Criteria:
--\> Inclusion Criteria: For hip surgery and chronic inflammation groups
* Male and female patients diagnosed with rheumatoid arthritis or undergoing an elective hip surgery
* Age \> 18 years old
* Understanding of French language and ability to give a written inform consent
For SARS-CoV-2 infection group
* Male and female patients diagnosed with SARS-CoV-2 infection (positive RT-PCR) and CRP \> 30 mg/L
* Age \> 18 years old
* Understanding of French language and ability to give a written inform consent
--\> Exclusion Criteria: For hip surgery and chronic inflammation groups
* Pregnant or lactating females
* Severe cardiac failure, severe edema or ascites
* Severe COPD or pulmonary embolism requiring oxygen
* Uncontrolled infection
* Active cancer
* HIV infection
* Renal impairment (defined as serum creatinine concentrations \> 1.5 x ULN)
* Hepatic impairment (alteration of hepatic tests AST, ALT, bilirubin, GGT \>2 x ULN)
* Inability to give blood samples
* Sensitivity to any of the drugs used
* Intake of drugs altering CYPs activity (based on \[1\]) except for tocilizumab
For SARS-CoV-2 infection group
* Pregnant or lactating females
* Hospitalized in intensive care unit at time of inclusion
* Hospitalized in intermediate care unit at time of inclusion
* Active cancer
* HIV infection
* Renal impairment (glomerular filtration rate \< 30 mL/min/1.73m2)
* Hepatic impairment (Child-Pugh score B and C)
* Inability to give blood samples
* Sensitivity to any of the drugs used
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Study:
NCT03262051
Study Brief:
Protocol Section:
NCT03262051