Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 11:35 PM
Ignite Modification Date:
2025-12-24 @ 11:35 PM
NCT ID:
NCT06572956
Eligibility Criteria:
Inclusion Criteria:
1. Recurrent or unresectable solid tumors (including pancreatic, prostate, breast, glioma, etc.).
2. Age over 15 and under 80.
3. KPS≥50 or ECOG score ≤2 and expected survival greater than 3 months.
4. No systemic therapy (except systemic immune checkpoint suppression or activation therapy) for at least 2 weeks or at least 5 drug half-lives (whichever is shorter) prior to apheresis.
5. The absolute number of neutrophils was \> 1.0x109 /L.
6. Absolute number of platelets \> 50x109 /L.
7. Absolute number of lymphocytes ≥ 0.2x109 /L.
8. ALT/AST \< 3 times normal value.
9. Total bilirubin \< 1.5mg/dl.
10. Creatinine \< 2.5mg/dl, or creatinine clearance ≥60 mL/min/1.73 m2.
11. The ejection fraction of heart ≥ 45%, echocardiography examination centerless fluid, electrocardiogram normal
12. Blood oxygen saturation ≥92% under normal environment.
13. Women of childbearing age who had a negative urine pregnancy test before dosing began and agreed to take effective contraception during the trial until the last follow-up visit.
14. Volunteer to participate in this experiment and sign the informed consent.
Exclusion Criteria:
* 1\) Those who are expected to survive less than 3 months. 2) Patients whose disease progression was so rapid that a complete treatment cycle could not be ensured at the time of enrollment as determined by the investigator.
3\) Patients with primary tumors other than melanoma skin cancer (unless cured for more than 3 years).
4\) Patients with infections including fungal, bacterial, viral or other uncontrolled infections or those requiring level 4 isolation.
5\) HIV, HBV, HCV positive patients. 6) Patients with central nervous system diseases including stroke, epilepsy, dementia or autoimmune central nervous system diseases.
7\) Myocardial infection, cardiac angiography or stenting, active angina pectoris or other significant clinical symptoms, or cardiogenic asthma or cardiovascular plasma cell infiltration in the 12 months prior to enrollment.
8\) Those who are receiving anticoagulation therapy or have severe coagulation dysfunction.
9\) The drug treatment that the patient is receiving will affect the safety and efficacy study of this project according to the judgment of the investigator.
10\) Patients with allergy or history of allergy to the biologics used in this project.
11\) Pregnant or lactating women. 12) Systematic use of systemic or systemic steroid drugs within 2 weeks prior to treatment (except those who have recently or currently used inhaled steroids).
13\) The efficiency of T cell transduction by replication-deficient lentivirus was less than 30%, or the ability to expand in response to CD3 / CD28 costimulatory signals was insufficient (\<5 times).
14\) Those who have other uncontrolled diseases that the researchers consider unsuitable for enrollment.
15\) Any situation that the investigator believes may increase the risk to the subject or interfere with the test results.
16\) Patients who are also participating in other clinical studies.
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
15 Years
Maximum Age:
80 Years
Study:
NCT06572956
Study Brief:
Protocol Section:
NCT06572956