Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 11:30 PM
Ignite Modification Date:
2025-12-24 @ 11:30 PM
NCT ID:
NCT06124456
Eligibility Criteria:
Inclusion Criteria:
* Cantonese, Mandarin, or English-speaking Chinese,
* aged 18-69,
* centrally obese according to the Asia-specific cut-off (waist circumference 90 cm for males, 80 cm for females) and BMI ≥23 (i.e., overweight as defined by the Hong Kong government),
* with NAFLD (defined as \>5% intrahepatic triglycerides assessed by 1H-MR spectroscopy),
* able to perform the prescribed exercise program. Both men and women will be included to enhance generalizability.
Exclusion Criteria:
* regular exercise training (\>3 sessions of \>60 min of moderate-intensity exercise training weekly) in the past 6 months,
* medical history of cardiovascular disease, chronic pulmonary or kidney disease, heart failure, cancer, and/or liver disease except NAFLD,
* somatic conditions that limit exercise participation (e.g., limb loss),
* impaired mobility due to chronic disease (e.g., chronic arthritis/osteoarthritis, neurological, musculoskeletal, and autoimmune diseases),
* daily smoking habit,
* excess alcohol consumption (daily ≥20 g of alcohol for men and ≥10 g for women) in the past 1 year,
* consumption of certain drugs (e.g., tamoxifen and estrogen) known to be secondary causes of steatosis,
* surgery and therapy for morbid obesity in the past 6 months and during the study period (e.g., gastric bypass, gastric band, sleeve gastrectomy, gastric reduction duodenal switch, or dietitian-prescribed dietary program).
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Maximum Age:
69 Years
Study:
NCT06124456
Study Brief:
Protocol Section:
NCT06124456