Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 11:30 PM
Ignite Modification Date:
2025-12-24 @ 11:30 PM
NCT ID:
NCT03546556
Eligibility Criteria:
Inclusion Criteria:
* Patients undergoing allogeneic bone marrow transplant for acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), or myelodysplastic syndrome
* Allogeneic transplant patients receiving either a fully myeloablative or reduced intensity chemotherapy +/- total body irradiation (TBI) conditioning regimen are eligible.
* Allogeneic transplant patients receiving stem cells from a matched related, matched unrelated, mismatched unrelated, mismatched related (including haplotype matched) donors are eligible
* Allogeneic transplant patients must be in a complete morphologic remission prior to transplant
* Patients undergoing autologous bone marrow transplant for multiple myeloma
* Myeloma patients must have achieved at least a very good partial remission prior to transplant and exhibit fewer than 10% plasma cells in their pre-transplant marrow biopsy
* At least 18 years of age
* Negative urine pregnancy test in women of child-bearing potential
Exclusion Criteria:
* Any woman who is pregnant or has reason to believe she is pregnant or any woman who is lactating.
* Condition that makes MRI unsafe (e.g., cardiac pacemaker, epicardial pacemaker leads, cochlear implants, metal aneurysm clip, metal halo devices)
* Inability to tolerate MRI (e.g., unable to lie flat for \> 1 hour, severe claustrophobia)
* Known allergy to fluorothymidine
* Creatinine clearance \< 40 ml/min, as estimated by the Cockcroft-Gault formula
* Body Mass Index (BMI) \> 35
* Poorly controlled diabetes mellitus (fasting blood glucose \> 500 mg/dl)
* Institutionalized subject (prisoner or nursing home patient)
* Critically ill or medically unstable
* Currently hospitalized (All FLT PET/MR scans will be obtained in the outpatient setting)
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Maximum Age:
99 Years
Study:
NCT03546556
Study Brief:
Protocol Section:
NCT03546556