Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-26 @ 11:00 AM
Ignite Modification Date:
2025-12-26 @ 11:00 AM
NCT ID:
NCT01246206
Eligibility Criteria:
Inclusion Criteria:
* Suitable related donor as determined by the treating physician
* High resolution molecular HLA typing is mandatory for HLA Class I and II
* Diagnosis of hematological malignancy
* Patients with one of the following hematologic malignancies, and felt to be transplant candidates by their treating physician are eligible to enroll on this protocol:
* Non-Hodgkin lymphoma, any complete remission (CR)/partial remission (PR)
* Hodgkin disease, any CR/PR/stable disease (SD)
* Acute myeloid leukemia (AML) or acute lymphoblastic leukemia (ALL) any CR; for non-CR AML or ALL, bone marrow blast \< 20% within 4 weeks of transplant and peripheral blood (PB) absolute blast count \< 500/μl on the day of initiation of conditioning
* Myelodysplastic syndrome (MDS), treated or untreated
* Chronic myelogenous leukemia (CML) in chronic phase or accelerated phase
* Chronic myelomonocytic leukemia (CMML)
* Multiple myeloma, any CR/PR/SD
* Chronic lymphocytic leukemia (CLL) any CR/PR
* Myelofibrosis and other myeloproliferative disorders; bone marrow blasts less than 20 percent within four weeks of transplant and peripheral blood absolute blast counts less than 500 per microliter on the day of initiation of conditioning
* Age \>= 18 and able to cooperate with oral medication intake
* Filgrastim (G-CSF) mobilized Peripheral blood stem cells
* Agrees to participate, and informed consent signed
* Karnofsky performance status (KPS) \>= 60, Eastern Cooperative Oncology Group (ECOG) performance status =\< 2
* Creatinine clearance \> 60 mL/min
* Ejection fraction \> 50%
* Serum bilirubin, alanine aminotransferase (ALT), aspartate aminotransferase (AST) less than 3 X upper limit of normal
* Forced vital capacity (FVC), forced expiratory volume in one second (FEV1) or diffusion capacity of carbon monoxide (DLCO) \> 50% predicted
Exclusion Criteria:
* Bone marrow or Ex vivo engineered or processed graft (cluster of differentiation \[CD\]34+ enrichment, T-cell depletion, etc)
* Patients with documented uncontrolled central nervous system (CNS) disease
* Active donor or recipient serology positive for human immunodeficiency virus (HIV)
* Known contraindication to administration of Tacrolimus or Thymoglobulin
* Active Hepatitis B or C
* Patients with coronary heart disease (recent myocardial infarctions, angina, cardiac stent, or bypass surgery in the last 6 months) need to be cleared with a stress echocardiogram or nuclear myocardial perfusion stress test, and cardiology consult; all other cardiac history will be at the discretion of the Principal Investigator
* Oxygen usage at the time of enrollment
* Patients with clinical ascites
* Women who are pregnant or nursing
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Maximum Age:
70 Years
Study:
NCT01246206
Study Brief:
Protocol Section:
NCT01246206