Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-26 @ 10:34 AM
Ignite Modification Date:
2025-12-26 @ 10:34 AM
NCT ID:
NCT06320028
Eligibility Criteria:
Inclusion Criteria:
* Participants must be between the ages of 18-50
* Participants must have normal or corrected vision (glasses, contacts, etc)
* Must be proficient in English in order to read the consent form (Spanish speakers are included, as long as they are also proficient in English)
* Must be right-handed
* Upper 25% of distribution on perseverative thinking scores based on local norms (score ≥ 37)
* Participants meeting DSM-5 criteria for current major depressive episode
Participants may be excluded from the MRI portion of the experiment if they are pregnant or are unsure if they may be pregnant or have any contraindications for MRI, including severe claustrophobia, non-MRI compatible cardiac pacemakers; implantable defibrillators; aneurysm clips; neural stimulators; artificial heart valves; ear implants; insulin pumps; drug infusion devices; IUDs; magnetic dental appliances; metal fragments or foreign objects in the eyes, skin or body; metal plates, screws, and prosthetics; non-removable metal piercings; tattoos on the head and neck, other certain older tattoos or permanent makeup (eyeliner) using metal-containing inks, some medicated patches, or any other condition, metal implant or other injury or device that is contraindicated for MRI. If a subject has any of these, the experimenter will evaluate whether it is safe for them to participate in the MRI portion of the experiment.
Exclusion Criteria:
* History of head injury with loss of consciousness for more than 5 min
* Uncorrected hearing or vision impairment severe enough to interfere with participation.
* Currently have or history of brain or mental illness judged likely to interfere with testing, including drug and/or alcohol dependence
* Sleep disorder (e.g., insomnia)
* Current drug, alcohol, or prescription drug intoxication
* History of epilepsy
* History of diagnosed migraines
* Metal implants in their head or face, including dental retainers that cannot be removed
* History of cardiac problems that could impact brain function (e.g., atrial fibrillation)
* Current active suicidal potential necessitating immediate treatment
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Maximum Age:
50 Years
Study:
NCT06320028
Study Brief:
Protocol Section:
NCT06320028