Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 11:24 PM
Ignite Modification Date:
2025-12-24 @ 11:24 PM
NCT ID:
NCT06181656
Eligibility Criteria:
Inclusion Criteria:
1. Group 1A
a. Patients currently receiving, planning to receive, or recently completed chemoradiation for esophageal cancer with protons.
2. Group 1B
a. Patients currently receiving, planning to receive, or recently completed chemoradiation for esophageal cancer with intensity-modulated radiation therapy (IMRT)
3. Group 2A
a. Patients currently receiving, planning to receive, or recently completed definitive proton therapy for unresectable hepatocellular carcinoma.
4. Group 2B
a. Patients currently receiving, planning to receive, or recently completed definitive IMRT for unresectable hepatocellular carcinoma.
5. Group 3
a. Healthy age- and gender- matched individuals
6. All Groups
1. Patients of all genders, races and nationalities will be solicited.
2. Age \>18 years
3. Ability to understand and the willingness to sign a written informed consent document.
Exclusion Criteria:
* Patients with compromised immunologic responses due to an uncontrolled intercurrent immunodeficiency (e.g., Human immunodeficiency virus (HIV), X-linked agammaglobulinemia) or previous or current immune suppressive therapy
a. Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible for this trial.
* Patients receiving intravenous immunoglobulin (IVIG) during the study or in the three months prior to study enrollment.
* Patients with psychiatric illness/social situations that would limit compliance with study requirements.
* Individuals with previous pneumococcal vaccination in the last 5 years.
* Individuals with severe allergy to any of the vaccine components
Healthy Volunteers:
True
Sex:
ALL
Minimum Age:
18 Years
Study:
NCT06181656
Study Brief:
Protocol Section:
NCT06181656