Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 11:20 PM
Ignite Modification Date:
2025-12-24 @ 11:20 PM
NCT ID:
NCT06140056
Eligibility Criteria:
Inclusion Criteria:
* Admitted to the ICU
* Invasive mechanical ventilation with FiO2 ≥ 50% OR PaO2-to-FiO2 ratio \<20 kPa, including PEEP 3 5 cmH20 for at least 6 hours
Exclusion Criteria:
* Meeting inclusion criteria for more than 24 hours
* Severe bronchospasm, defined as warranting treatment aimed at reversing this i.e. inhalation of anticholinergic or bronchodilator beyond what the patient normally use
* Emphysema where treating physician judges the patient at increased risk for pneumothorax from APRV
* Restrictive lung disease defined as a pre-admission diagnosis of restrictive lung disease
* Undrained pneumothorax
* Hemodynamic instability defined as more than 0.20 microgram/kg/min of norepinephrine or any dose of adrenaline infusion to maintain MAP ≥ 65 mmHg
* Age \< 18 years
* Patients who have received APRV previously during the current ICU admission
* Patients in prone position within the last 24 hours
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Study:
NCT06140056
Study Brief:
Protocol Section:
NCT06140056