Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 11:16 PM
Ignite Modification Date:
2025-12-24 @ 11:16 PM
NCT ID:
NCT00352456
Eligibility Criteria:
* INCLUSION CRITERIA:
1. Psychopathy:
1. Comparison individuals: All individuals will score less than 20 on the PCL-R.
2. Individuals with psychopathy: All individuals will score more than 30 on the PCL-R (participants scoring between 21-29 are excluded from study participation).
2. Age: Participants will be males and females, 20-50 years of age.
3. IQ: IQ, as measured by 4 subscales from the Wechsler Adult Intelligence Scale-Revised (WAIS-R), must be greater than 80.
4. Medication status: No current use of any psychotropic medication or benzodiazepine.
EXCLUSION CRITERIA:
Because factors such as psychiatric disease, or CNS disease, can influence functional brain activity, these factors are exclusionary.
1. Psychiatric history: Participants will be assessed using DSM-IV criteria via standardized psychiatric interviews conducted by trained examiners (i.e., SCID).
1. Comparison individuals: All participants will be free of any current or past psychiatric disorder. Participants will be excluded if they meet criteria for substance dependence but not if they meet criteria for substance abuse.
2. Individuals with psychopathy: It is to be expected that the individuals with psychopathy will meet diagnostic criteria for Antisocial Personality Disorder and, in childhood, would have met criteria for Conduct Disorder, Oppositional Defiant Disorder and probably Attentional Deficit and Hyperactivity Disorder. Any other current or past psychiatric disorder will be exclusory. Participants will be excluded if they meet criteria for substance dependence but not if they meet criteria for substance abuse.
2. Severe acute and chronic medical illnesses. In short, any condition requiring the administration of systemic drugs will be exclusory.
3. CNS disease: history of brain abnormalities (e.g., neoplasms, subarachnoid cysts), cerebrovascular disease, infectious disease (e.g., abscess), or other neurological disease, or history of head trauma (defined as loss of consciousness greater than 3 min).
4. Metal or electronic objects: Metal plates, certain types of dental braces, cardiac pacemakers, etc., that are sensitive to electromagnetic fields contraindicate MRI scans.
5. Claustrophobia: participants will be questioned about potential discomfort in being in an enclosed space, such as an MRI scanner.
6. There will be no exclusion criteria as regards type of crime. While there is some increase in risk to testers in having participants who have committed acts of violence, it is not extreme as long as the participants are appropriately treated. Indeed, in our previous work almost all of our participants (comparison individuals and individuals with psychopathy) were murderers.
Healthy Volunteers:
True
Sex:
ALL
Minimum Age:
20 Years
Maximum Age:
50 Years
Study:
NCT00352456
Study Brief:
Protocol Section:
NCT00352456