Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 11:15 PM
Ignite Modification Date:
2025-12-24 @ 11:15 PM
NCT ID:
NCT02055456
Eligibility Criteria:
Inclusion Criteria:
* Peripheral blood leukocytes telomeres short for age, below the first percentile of a curve based on 500 healthy individuals between 0 and 100 years, with or without a telomerase gene mutation.
AND
* One or more of the following cytopenias:
Anemia (symptoms of anemia with hemoglobin \<9.5 g/dL, or need for transfusion \> 2 units of packed red blood cells/month for at least two months, or absolute reticulocytes count \<60.000/μL).
Thrombocytopenia (platelets counts \<30.000/μL or \<50.000/μL associated with bleeding, or megakaryocytes reduction in the bone marrow).
Neutropenia (absolute neutrophil counts \<1.000/μL).
OR
* Idiopathic pulmonary fibrosis diagnosed according to the American Thoracic Society (ATS) criteria.
Exclusion Criteria:
* Terminal disease or liver disease, renal, cardiac, neurological, infectious or concomitant metabolic state whose gravity prevents the ability of the patient to tolerate the treatment protocol, or probable death within 30 days.
* People with cancer who are undergoing chemotherapy.
* Pregnancy, or desire to not prevent pregnancy in childbearing age.
* Aplastic Anemia patients with indication for bone marrow transplantation and matched donor.
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
2 Years
Maximum Age:
99 Years
Study:
NCT02055456
Study Brief:
Protocol Section:
NCT02055456