Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 11:13 PM
Ignite Modification Date:
2025-12-24 @ 11:13 PM
NCT ID:
NCT00972569
Eligibility Criteria:
Inclusion Criteria:
* Patients admitted to St Mary's Hospital, Mayo Clinic Rochester MN with NYHA class III-IV decompensated CHF with renal dysfunction as Calculated creatinine clearance of equal or less than 60 ml/min but greater than 20 ml/min using the Cockcroft-Gault formula.
Exclusion Criteria:
* Cause of acute renal dysfunction can be reasonably ascribed to factors other than heart failure or its treatment
* Known intrinsic renal diseases or renal artery stenosis of =\>50%
* Patients taking Nitrates within the previous 24 hours
* Patients needing emergency coronary revascularization or those who may have rapidly changing cardiac function (i.e. patients with acute myocardial infarction or shock)
* Peritoneal or hemodialysis within 90 days or anticipation that dialysis or ultrafiltration of any form will be required during the study period
* Systolic blood pressure \< 90 mmHg or cardiogenic shock.
* Requirement of pressors for maintenance of blood pressure.
* Intra-aortic blood pump use.
* History of significant uncorrected renal artery stenosis as defined by \>50% stenosis.
* Severe aortic or mitral stenosis or significant LV outflow tract obstruction. Hgb \< 10 mg/dL
* Pregnant or nursing women.
* Contraindication to nesiritide.
* Inability to have NSAID dose held for up to 30 hours, if being treated with these medications.
* Administration of radiocontrast medium within 7 days of enrollment or anticipated use of such agents during the study
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Study:
NCT00972569
Study Brief:
Protocol Section:
NCT00972569