Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 1:32 PM
Ignite Modification Date:
2025-12-24 @ 1:32 PM
NCT ID:
NCT03537495
Eligibility Criteria:
Inclusion Criteria:
* Age: 18 years old or older
* Clinically diagnosed as TB meningitis patient
* CSF/blood glucose ratio \< 0.5
* Willing to participate in the study by signing informed consent
Exclusion Criteria:
Patients who have one of the following criteria will be excluded:
* Failure to diagnostic lumbar puncture
* Confirmed cryptococcus meningitis (LFA) in HIV-positive patients; or diagnosed as bacterial meningitis based on clinical assessment and routine CSF examination.
* Treatment for tuberculosis for more than 3 days before admission
* History of TBM
* Current treatment with: MAO inhibitors, direct and indirect acting sympathomimetic drugs, vasopressive drugs, dopaminergic compounds, buspiron, serotonin reuptake inhibitors, tricyclic antidepressants, triptans, tramadol and meperidine
* History (\< 2 weeks before start of linezolid) of taking any MAO inhibitors
* Pregnant or lactating females
* Hepatic insufficiency (ALT\>5x upper normal limit)
* Kidney dysfunction (eGFR \<50ml/min)
* Known hypersensitivity to rifampicin and/or linezolid
* Rapid clinical deterioration at time of presentation (sepsis, decreasing consciousness, or signs of cerebral oedema or herniation)
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Study:
NCT03537495
Study Brief:
Protocol Section:
NCT03537495