Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 10:48 PM
Ignite Modification Date:
2025-12-24 @ 10:48 PM
NCT ID:
NCT00574769
Eligibility Criteria:
Inclusion Criteria:
* Age ≥ 18 years.
* Signed informed consent
* ECOG performance status: 0-2
* Histologically documented adenocarcinoma of the prostate
* Progressive disease despite androgen deprivation therapy. Progressive disease is defined as any one of the following:
* Measurable Disease: Objective evidence of increase \> 20% in the sum of the longest diameters of target lesions from the time of maximal regression or the appearance of one or more new lesions (Modified RECIST Criteria)
* Bone Scan Progression: Appearance of one or more new lesions on bone scan attributable to prostate cancer
* PSA Progression: An elevated PSA (≥ 5 ng/ml) which has risen serially from baseline on two occasions each at least one week apart
* At least 4 weeks since any other hormonal therapy. Flutamide and megestrol acetate (any dose) must be discontinued at least 4 weeks prior to initiating treatment. Bicalutamide or nilutamide must be discontinued at least 6 weeks prior to initiating treatment. If improvement following antiandrogen withdrawal is noted, progression must be established using the criteria above. Androgen suppression should be continued
* ≥ 4 weeks since major surgery and fully recovered
* ≥ 8 weeks since high risk surgery and fully recovered
* ≥ 4 weeks since any prior radiation and fully recovered
* ≥ 6 weeks since the last dose of bone targeted radiopharmaceutical
* Men of child-bearing potential are required to use an effective means of contraception
* Required Initial Laboratory Values:
* ANC ≥ 1500/µL
* Platelet count ≥ 100,000/µL
* Creatinine ≤ 1.5 x ULN
* Bilirubin ≤ 1.5 x ULN
* AST ≤ 1.5 x ULN
* Urine protein to creatinine ratio \< 1.0
* Serum Testosterone ≤ 50 ng/dL (For patients who have not had bilateral orchiectomy.)
Exclusion Criteria:
* Prior treatment with cytotoxic chemotherapy for metastatic disease
* Prior treatment with anti-angiogenic agents, including thalidomide and bevacizumab
* Prior treatment with any investigational drug within 4 weeks of initiating treatment
* Prior treatment with an mTor inhibitor
* Chronic treatment with systemic steroids or another immunosuppressive agent
* Known history of HIV seropositivity
* Known brain metastases (brain imaging is not required)
* Congestive heart failure
* Uncontrolled hypertension. Patients with history of hypertension must be well controlled (\< 150/100) on a regimen of anti-hypertensive therapy
* Any prior history of hypertensive crisis or hypertensive encephalopathy
* Impairment of gastrointestinal function or gastrointestinal disease that may significantly alter the absorption of RAD001
* History of abdominal fistula, gastrointestinal perforation, or intra-abdominal abscess within 6 months prior to study enrollment
* Active bleeding diathesis or on oral anti-vitamin K medications (except low dose coumarin)
* Arterial thrombotic events, including transient ischemic attack (TIA), cerebrovascular accident (CVA), at any time
* History of unstable angina or angina requiring surgical or medical intervention in the past 12 months, or myocardial infarction (MI)
* Patients with clinically significant peripheral artery disease or any other arterial thrombotic event
* Significant vascular disease
* Other concurrent severe and/or uncontrolled medical disease which could compromise participation in the study
* Proteinuria at screening as demonstrated by either
* Urine protein:creatinine (UPC) ratio ≥ 1.0 OR
* Urine dipstick for proteinuria ≥ 2+
* Serious or non-healing wound, ulcer or bone fracture
* Peripheral neuropathy ≥ grade 2
* Known hypersensitivity to Chinese hamster ovary cell products or other recombinant human antibodies
* Herbal medications and food supplements must be discontinued before registration. Patients may continue on daily vitamins and calcium supplements
* History of noncompliance to medical regimens
* Unwilling to or unable to comply with the protocol
Healthy Volunteers:
False
Sex:
MALE
Minimum Age:
18 Years
Study:
NCT00574769
Study Brief:
Protocol Section:
NCT00574769