Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 10:40 PM
Ignite Modification Date:
2025-12-24 @ 10:40 PM
NCT ID:
NCT04015635
Eligibility Criteria:
Inclusion Criteria:
* Age between 18-55 years
* Cases: Office blood pressure ≥140 and ≥90
* Controls: Office blood pressure \<140 and \<90 and age, sex and BMI matching to cases
Exclusion Criteria:
* Age \>55 years old;
* Secondary hypertension (including e.g. adrenal tumours, pheochromocytoma, renal artery stenosis; thyroid disease)
* Acute inflammatory disorders incl. flu, rhinitis, sinusitis etc. within 3 weeks;
* hospitalization within the past 3 months;
* Life expectancy of \< 3 years;
* History of alcohol/substance abuse
* Inflammatory conditions e.g. Allergic disorders; chronic infections, COPD, tuberculosis; hepatitis B or C; pneumonitis, bronchiectasis; pericardial or pleural effusion, ascites; liver disease;
* Chronic inflammatory/autoimmune conditions such (e.g. SLE, rheumatoid arthritis, ulcerative colitis/Crohn's disease; non-basal cell malignancy or myelo- or lymphoproliferative disease within the past 5 years; known HIV+; Immunizations (3 months); pulmonary hypertension;
* Pregnancy, nursing;
* History of symptomatic coronary artery disease (events) or heart failure;
* BMI\>40,
* diabetes/glucose intolerance (fasting glucose, HbA1; testing, glucose challenge where indicated);
* Known albuminuria/microalbuminuria;
* GFR\<60mL/min/1.73m2.
* Any chronic concurrent treatment: Use of systemic or local steroids/immunosuppressive agents (within 6 months) of the inclusion; Current (within past 3 months) use of anti-hypertensive medication;
* Major depressive illness or other psychiatric conditions.
* Participants who decline participation in the study or who are unable to provide informed consent
Healthy Volunteers:
True
Sex:
ALL
Minimum Age:
18 Years
Maximum Age:
55 Years
Study:
NCT04015635
Study Brief:
Protocol Section:
NCT04015635