Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 10:22 PM
Ignite Modification Date:
2025-12-24 @ 10:22 PM
NCT ID:
NCT04313335
Eligibility Criteria:
Inclusion Criteria:
* ages more than 50 years;
* diagnosed with uncomplicated acute herpes zoster;
* presents with vesicles within 72 hours;
* has an average pain score of at least 40/100 mm on a visual analog scale (VAS, 0 = no pain, 100 = worst possible pain, at opposite ends of a 100-mm line).
Exclusion Criteria:
* refuses to participate or to provide written informed consent;
* Zung Self-Rating Depression Scale raw score of more than 50 points;
* herpes zoster that involves with head, neck, ocular, mucous membrane, cranial nerve, or central nervous system;
* has hemorrhagic or necrotizing lesions, satellite lesions, abnormal vesicles or acute retinal necrosis;
* has been on immunosuppressive therapy or mono- or multi-pharmacotherapy that involves any tricyclic antidepressant, valacyclovir, duloxetine or cytotoxic medications before acute HZ onset;
* has been diagnosed with hepatic, renal or immune dysfunction;
* during pregnancy or breastfeeding at the time;
* hypersensitivity to the study drugs;
* has contraindications to valacyclovir or duloxetine;
* HZ vaccinated.
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
50 Years
Study:
NCT04313335
Study Brief:
Protocol Section:
NCT04313335