Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 10:16 PM
Ignite Modification Date:
2025-12-24 @ 10:16 PM
NCT ID:
NCT05756335
Eligibility Criteria:
Inclusion Criteria:
* Adults aged 21-35.
* No contraindications to MRI or PET scanning.
* Right-handed.
* Fluent to speak, read, and understand English.
Exclusion Criteria:
* Adults unable to consent
* Contraindications to fMRI scanning and PET scanning (including the presence of a cardiac pacemaker or pacemaker wires, metallic particles in the body, vascular clips in the head or previous neurosurgery, prosthetic heart valves, claustrophobia)
* Inability to lie motionless in the scanner
* Pregnancy, seeking or suspecting pregnancy, or breastfeeding
* History of major head trauma
* Intracranial lesion
* Cardiovascular disorders, including heart disorders or high blood pressure \[\>155/95\]
* Breathing problems such as severe asthma, emphysema, or pulmonary disease
* Bleeding disorder, or use of anticoagulants
* Bladder obstruction, urinary problems, or history of impaired elimination
* Known kidney or liver problems
* Past severe COVID-19 infection
* Intestinal blockage
* Raynaud syndrome
* Anemia
* Peripheral nerve injury
* Diabetes
* Glaucoma
* Current or recent use of medications (neurological or psychiatric) affecting brain function
* Current or past history of major medical, neurological, or psychiatric condition
* Current or past history of chronic pain (assessed at the discretion of PI)
* Current smoker
* Body mass index above 35
* Research-related radiation exposure exceeds current Radiology Department guidelines
* Lack of current health insurance coverage
* Employed under the direct supervision of the investigators conducting the research
* Unwilling or unable to cooperate with breathing maneuvers required during the gas challenge
* Respiratory or cardiac limitations to breathing at 20 L/min
Healthy Volunteers:
True
Sex:
ALL
Minimum Age:
21 Years
Maximum Age:
35 Years
Study:
NCT05756335
Study Brief:
Protocol Section:
NCT05756335