Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 10:16 PM
Ignite Modification Date:
2025-12-24 @ 10:16 PM
NCT ID:
NCT04604535
Eligibility Criteria:
Inclusion Criteria:
* Aged ≥18
* Able to give written informed consent
* Singleton pregnancies, between 24+0 to 36+6 weeks gestation with new onset gestational hypertension (defined by ISSHP2018 as new onset BP \>140/90 and no evidence of proteinuria, biochemical or haematological abnormalities or fetal growth restriction) Or
* Singleton pregnancies, between 24+0 - 36+6 weeks gestation, with chronic hypertension (defined by ISSHP2018 as BP ≥140/90 predating the pregnancy or recognised at \<20 week's gestation) Or
* Singleton pregnancies, between 24+0 - 36+6 weeks gestation, with preeclampsia (defined by ISSHP2018 as Gestational hypertension accompanied by ≥ 1 of the following new onset conditions at or after 20 weeks' gestation:
* Proteinuria (24h urine collection\>300mg/day, Protein-creatinine ratio\>30 mg/mmol)
* Other markers of maternal organ dysfunction, including:
* Acute Kidney Injury (AKI) (creatinine ≥90μmol/L; 1mg/dL)
* Liver involvement (elevated transaminases e.g. alanine transaminase (ALT) or aspartate aminotransferase (AST) \>40IU/L) with or without right upper quadrant or epigastric abdominal pain
* Neurological complications e.g. eclampsia, altered mental status, blindness, stroke, clonus, severe headaches and persistent visual scotomata
* Haematological complications (thrombocytopenia - platelet count \<150 000/μL, disseminated intravascular coagulation, haemolysis
* Uteroplacental dysfunction (fetal growth restriction, abnormal umbilical artery doppler wave form analysis, or stillbirth)
Exclusion Criteria:
* Unable to tolerate taste of beetroot juice concentrate during taste test
* Multiple pregnancy
* History of acute or chronic liver conditions (aside from preeclampsia)
* Fetal aneuploidies or major fetal anomalies
* Unwillingness to comply with all study-related procedures e.g. Women who have used mouthwash or tongue scraping in last 7 days and are not able/unwilling unable to stop this for the duration of the study
* Women on treatment for gingivitis
* Women with persistent hyperemesis or ptyalism
* On Proton-pump-inhibitors/antacids other treatment for gastritis/peptic ulcer/gastric ulcers
* Those with long term antibiotic use e.g. prophylaxis of urinary tract infections (UTIs) or those who are likely to need repeated courses of antibiotics e.g. history of recurrent UTI
* Women with known allergy/intolerance to beetroot or lemon
* Type 1 and Type 2 diabetics
* Moderate iron deficiency anaemia with haemoglobin \<100g/dL and/or ferritin \<15μg/L
* Any blood disorder or significant illness that may affect platelet function and coagulation. However, patients taking low-dose aspirin (150mg) for preeclampsia prophylaxis who are at increased risk of developing preeclampsia will be included in the study.
* History of alcohol or recreational drug abuse use within the past 6 months
* Systemic autoimmune disease e.g. Rheumatoid Arthritis, antiphospholipid syndrome connective tissue disease e.g. Systemic Lupus Erythematous or other conditions known to be associated with chronic inflammation such as inflammatory bowel disease - Chron's disease/Ulcerative Colitis
* Women not intending to deliver at the recruiting site
* Participating in another intervention study that influences the outcomes of this study
* Those with serious mental illness or learning difficulties and unable to give written informed consent
* Those who are detained as a prisoner or detained in any secured unit, including those held under the Mental Health Act
* Those not fluent in local language, and absence of appropriate interpreter despite use of services such as Language Line
Healthy Volunteers:
True
Sex:
FEMALE
Minimum Age:
18 Years
Study:
NCT04604535
Study Brief:
Protocol Section:
NCT04604535