Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 10:15 PM
Ignite Modification Date:
2025-12-24 @ 10:15 PM
NCT ID:
NCT00271635
Eligibility Criteria:
Inclusion Criteria:
* DNA-proven CMT1A patients
* Age 12-25 years
* CMT 1A patients with symptomatology defined as muscle weakness in at least foot dorsiflexion
Exclusion Criteria:
Due to possible influence on severity of the neuropathy:
* Known other disease that may cause a neuropathy, that may decrease mobility, or that may lead to severe disability or death in a short time
* Medication that may cause a neuropathy
* Chronic alcohol abuse
Due to study medication (ascorbic acid):
* Regular use of vitamin C
* Clinical or echographic signs of nephrolithiasis
* Reduced glomerular filtration rate
* Iron overload
* No regular dental control at the dentist
* Pregnancy or active pregnancy wish for women
Due to study design and primary outcome:
* Not signing the informed consent
* Psychiatric co-morbidity which may influence compliance
* Not being comfortable during nerve conduction studies of the median nerve
* A too small CMAP amplitude of the abductor pollicis brevis muscle for a proper determination of the nerve conduction velocity of the median nerve
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
12 Years
Maximum Age:
25 Years
Study:
NCT00271635
Study Brief:
Protocol Section:
NCT00271635