Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 10:09 PM
Ignite Modification Date:
2025-12-24 @ 10:09 PM
NCT ID:
NCT02297035
Eligibility Criteria:
Inclusion criteria A) Patients responding to current diagnostic criteria for Primary Progressive Aphasia
1. Language disorders without important impairments of other cognitive functions
2. Insidious onset and gradual progression
* Diagnostic criteria for non fluent PPA
* Non fluent language out-put
* Phonemic paraphasias and/or agrammatism
* Relative preservation of speech comprehension
* Diagnostic criteria for fluent PPA
* Fluent language out-put
* Impairment of the access to word meanings leading to comprehension disorders and naming deficits
* Associative agnosia and/or prosopagnosia may be present. This will allow for the inclusion of patients with multi-modal disorders of meaning (semantic dementia patients).
* Diagnostic criteria for logopenic PPA
* Speech out-put with frequent interruptions due to word finding deficits
* Disorders of sentence comprehension and repetition due to impairment of working memory B) Patients at age of majority C) Patients having given informed and written consent
Exclusion criteria A) Cognitive criteria
* Aphasia severity rating scale of the BDAE \< 3
* MMS \< 20
* Severe disorders of executive functions, praxis or episodic memory B) MADRS ≥ 20 (major depression as defined by criteria of the DSM-IV-R) C) Patients whose mother tongue is not French D) Patients affected by of other neurological diseases than PPA or general diseases or physical problems that may impact on cognitive functioning E) Counter-indication for MRI or PET scanning (the lumbar puncture is optional / separated informed consent) F) MRI compatible with pathological processes other than PPA. A mild to moderate leucoaraiosis will not been considered as an exclusion criteria (only patients at stage \> 2 will be excluded from the study) G) Non affiliation at the French healthcare system
Healthy Volunteers:
True
Sex:
ALL
Minimum Age:
18 Years
Study:
NCT02297035
Study Brief:
Protocol Section:
NCT02297035