Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 10:02 PM
Ignite Modification Date:
2025-12-24 @ 10:02 PM
NCT ID:
NCT04331132
Eligibility Criteria:
Inclusion Criteria:
* Admitted to hospital with a primary diagnosis of acute heart failure with wet-warm phenotype
* Cumulative urine volume output \< 300ml within 2 hours after the first dose of intravenous furosemide
* eGFR at admission 15-60ml/min/1.73m2
Exclusion Criteria:
* Acute coronary syndrome
* Anuria
* Sepsis
* Consciousness impairment
* Pregnant or breastfeeding women
* Severe valvular heart diseases (severe valvular stenosis or regurgitation)
* Admission sodium level \> 140 mEq/L
* Serum total bilirubin \> 3 mg/dL
* Serum potassium \> 5.5 mmol/L
* Allergy or contraindication for tolvaptan
* Emergency indication for hemodialysis
* Cardiogenic shock or mechanical circulation support
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
20 Years
Maximum Age:
75 Years
Study:
NCT04331132
Study Brief:
Protocol Section:
NCT04331132