Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 9:58 PM
Ignite Modification Date:
2025-12-24 @ 9:58 PM
NCT ID:
NCT05402332
Eligibility Criteria:
Inclusion Criteria
1. Subject is aged 18 to 60 years.
2. Subject has biologically and genetically proven PGM1-CDG.
3. Subject is currently on a stable dose of D-galactose therapy.
4. Non-pregnant, non-lactating female subjects of childbearing potential who are heterosexually active and non-sterile male subjects with female sexual partners of childbearing potential agree to use a highly effective method of contraception for the duration of the study, including the long-term safety follow-up period. A highly effective method of birth control is defined as one that results in a low failure rate (i.e., \<1% per year) when used consistently and correctly, such as oral/injectable/inserted/implanted/transdermal contraceptives, condom with diaphragm, condom with spermicide, diaphragm with spermicide, intrauterine hormone- releasing system, or intrauterine device (IUD), or sexual abstinence. Contraception is not required where at least 6 weeks have passed since sterilization, defined as females having undergone one of the following surgeries: hysterectomy, bilateral tubal ligation or occlusion, bilateral oophorectomy, or bilateral salpingectomy; and males who are vasectomized. Contraception is not required where females are postmenopausal (defined as 12 consecutive months of spontaneous amenorrhea and age ≥51 years).
5. Subject/legally authorized representative (LAR) is able to understand and provide written informed consent, and assent (as applicable) to participate in this study.
Exclusion Criteria
1. Subject has aldolase B deficiency, galactosemia, hemolytic uremic syndrome, or severe anemia.
2. In the site Principal Investigator's opinion, subject has a history of galactose intolerance that precludes the subject from participation in this study.
3. In the site Principal Investigator's opinion, subject has previously experienced any of the following severe AEs from oral galactose:
1. Severe diarrhea
2. Severe, recurrent vomiting
3. Constipation
4. Galactosuria
5. Increased liver glycogen storage.
4. Subject has any of the following:
1. Liver failure
2. ALT level \>8x ULN
3. AST level \>8x ULN
5. Use of investigational compounds within the previous 6 months or current enrollment in another trial involving investigational compounds.
6. Subject is pregnant.
7. Subject has hepatic impairment that would require a dose adjustment, defined by the site Principal Investigator.
8. In the site Principal Investigator's opinion, subject is not able or willing to comply with the trial requirements.
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Maximum Age:
60 Years
Study:
NCT05402332
Study Brief:
Protocol Section:
NCT05402332