Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 9:55 PM
Ignite Modification Date:
2025-12-24 @ 9:55 PM
NCT ID:
NCT04080232
Eligibility Criteria:
Inclusion Criteria:
* Patient ≥ 18 yo ;
* Patient who underwent an allogeneic stem cell transplantation (SCT)
* \> 3 months post-SCT
* With evidence of
* respiratory symptoms, and/or
* Pathological PFTs defined by : obstructive syndrome (FEV1 :vital capacity/CVF \< 0.7), FEV1 \< 0.75 of pre-SCT values, residual volume \> 120%, and/or ;
* Altered PFTs consistent with 0p stage described in lung transplantation BOS: FEV1 decline ≥ 10 % and/or FEF25-75 decline ≥ 25% compared to pre-SCT PFTs, and/or ;
* Abnormal chest CT-scan with findings consistent with BOS: evidence of air trapping on expiratory CT-scan, bronchiectasis, and/or airway thickening.
Exclusion Criteria:
* Contraindication for MRI ;
* Contraindication of oxygen administration ;
* Decompensation of altered respiratory function ;
* Acute respiratory infection (bacterial, fungal or viral) documented in the last 6 weeks ;
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Study:
NCT04080232
Study Brief:
Protocol Section:
NCT04080232