Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 9:43 PM
Ignite Modification Date:
2025-12-24 @ 9:43 PM
NCT ID:
NCT00923832
Eligibility Criteria:
* INCLUSION CRITERIA:
Patients currently enrolled in any NIH IRB approved Clinical Center protocol or under treatment at the CNMC who are undergoing bronchoscopy or lung biopsy for diagnosis of possible invasive pulmonary aspergillosis or invasive pulmonary zygomycosis.
Informed consent of the patient or the patient's legally authorized representative.
Fulfillment of one or more of the following EORTC/MSG host criteria:
* History of neutropenia (ANC \< 500/mm(3)) within the past 3 months temporally related to the onset of radiographic changes
* Receipt of an allogeneic HSCT
* Receipt of solid organ transplantation
* Prolonged use of corticosteroids at an average minimum dose of 0.3 mg/kg/day prednisone equivalent for \> 3 weeks
* Treatment with other recognized T-cell immune suppressants such as cyclosporine, TNF alpha blockers, specific monoclonal antibodies such as alemtuzumab, nucleoside analogues during the past 90 days
* Myelodysplastic syndrome
* Severe aplastic anemia
* Cushing's disease
* HIV/AIDS
* Primary immunodeficiencies (such as chronic granulomatous disease, severe combined immunodeficiency)
The presence of one or more of the following signs on chest CT or radiograph:
* Dense well circumscribed lesions with or without a halo sign
* Air crescent sign
* Cavity
* Focal, segmental or lobar infiltrates
EXCLUSION CRITERIA:
Interstitial or diffuse infiltrates on chest CT or radiograph
Inability to provide informed consent
Children weighing less than 10 kg
Any other concomitant condition, which in the opinion of the investigator would place the patient at risk by participating in the study
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
1 Year
Maximum Age:
99 Years
Study:
NCT00923832
Study Brief:
Protocol Section:
NCT00923832