Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 9:42 PM
Ignite Modification Date:
2025-12-24 @ 9:42 PM
NCT ID:
NCT00947232
Eligibility Criteria:
Inclusion Criteria:
* aged at least 45 years old
* self-report diagnosis of MS or SCI
* meeting SCID requirements for Major Depressive Disorder (MDD) or dysthymia
* MS: EDSS between 4.0 and 8.0
* SCI: ASIA A-D injury level at or below C4 and they have upper extremity function sufficient to propel a manual wheelchair
* meeting PHQ-9 measure cut-off for depression by scoring more than 10 on the measure
* currently inactive (exercising less than 150 minutes per week)
* response form received from participants' doctor declaring exercise safe for the subject.
Exclusion Criteria:
* significant cognitive impairment
* pressure ulcers on sitting surfaces (or another condition that precludes sitting
* significant obesity (\>160% of ideal body weight)
* significant risk factors for beginning moderate physical activity measured with the PAR-Q
* response form received from participants' doctor declaring exercise unsafe for the subject
* a self-reported history of significant Uthoff's effect for those with MS
* psychiatric contraindications such as bipolar disorder, psychosis, active suicidal ideation with intent or plan, or current alcohol or drug dependence. We will include people who remain depressed but are on stable doses of antidepressant medications.
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
45 Years
Study:
NCT00947232
Study Brief:
Protocol Section:
NCT00947232