Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 9:41 PM
Ignite Modification Date:
2025-12-24 @ 9:41 PM
NCT ID:
NCT02153632
Eligibility Criteria:
Inclusion Criteria:
* Signed Institutional Review Board (IRB)/ Independent Ethics Committee (IEC) informed consent form.
* Idiopathic Parkinson's disease per the United Kingdom (UK) Parkinson's Disease Society Brain Bank criteria.
* Male or female 30 to 85 years old.
* Levodopa induced, predictable peak-effect dyskinesia considered problematic and/or disabling.
* Screening serum creatinine level within normal range
* On stable doses of all oral anti-Parkinson's medication, including any levodopa preparation, for 30 days and be willing to remain on the same doses throughout the trial.
* The subject/caregiver must demonstrate the ability to complete an accurate home diary based on training and evaluation during the screening period.
Exclusion Criteria:
* Secondary parkinsonian syndrome, such as vascular, postinflammatory,drug-induced, neoplastic and post-traumatic parkinsonism or any atypical parkinsonian syndrome (e.g., Progressive Supranuclear Palsy, Multi-System Atrophy, etc.);
* Use of amantadine within 14 days before study start, or previously had an adverse event to amantadine
* Currently taking neuroleptics and atypical antipsychotic agents, acetylcholinesterase inhibitors, apomorphine, rimantadine, memantine and dextromethorphan and quinidine if used in combination for treating dyskinesia.
* History of neurosurgical intervention for treating Parkinson's s disease (i.e. pallidotomy or implanted with a deep brain stimulator)
* Any medical condition or past medical history that would increase the risk of exposure to Amantadine HCl Extended Release Tablets or interfere with safety and efficacy evaluations.
* History of cancer within 5 years of screening with following exceptions: adequately treated non-melanomatous skin cancers, localized bladder cancer, non-metastatic prostate cancer or in situ cervical cancer.
* History or current diagnosis of schizophrenia or bipolar disorder;
* Inadequately treated Major Depressive Disorder. Subjects on stable doses of selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIs) are eligible for the study;
* Is at imminent risk of suicide or had a suicide attempt within 6 months of screening
* History or current diagnosis of Impulse Control Disorder
* Calculated plasma creatinine clearance of \<60 mL/min at screening
* History of or currently has any of the following clinically significant conditions, cardiovascular, respiratory, renal, hepatic, or gastrointestinal disease
* Any clinically significant vital sign, ECG, or laboratory abnormalities;
* A positive test for HIV antibody or history of HIV; hepatitis B surface antigen unless the positive test followed a recent (\<28 days) vaccination for hepatitis B; hepatitis C antibody;
* A positive urine drug test.
* Pregnant or breastfeeding at screening or has a positive pregnancy test
* If a sexually active female, is not surgically sterile or at least 2 years post-menopausal, or does not agree to utilize an effective method of contraception from the screening visit to at least 4 weeks after the completion of study treatment.
* History of alcohol or narcotic substance abuse ≤1 year before screening.
* Has dementia or another psychiatric illness that prevents provision of informed consent.
* Has a known hypersensitivity to the study treatment(s), based on known allergies to drugs of the same class including rimantadine HCl and memantine HCl.
* Has participated in other studies involving investigational drugs or surgeries within the last 30 days or investigational biologics within the last 6 months prior to screening.
* Plans to undergo major elective surgery during the course of the study.
* Received administration of Live Attenuated Influenza Vaccine (LAIV) within 2 weeks.
* Cognitive impairment, as evidenced by a score \<26 on the Montreal Cognitive Assessment (MoCA) at the screening visit.
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
30 Years
Maximum Age:
85 Years
Study:
NCT02153632
Study Brief:
Protocol Section:
NCT02153632