Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 9:39 PM
Ignite Modification Date:
2025-12-24 @ 9:39 PM
NCT ID:
NCT00610532
Eligibility Criteria:
Inclusion Criteria:
* Men with pharmacoresistant partial epilepsy defined as failure of two or more AEDs at a reasonable therapeutic dose
* Patient is able to understand and sign a consent form and able to keep a seizure calendar
* Patient is older than 18 years of age
* Patient is otherwise healthy by laboratory and physical examination
Exclusion Criteria:
* Patient is currently taking phenytoin
* Patient has a history of an adverse reaction to phenytoin
* Patient has a history of gout disease, peptic ulcer disease, blood dyscrasias, or uric acid kidney stones
* Patient has an allergy to sulfa drugs or probenecid
* Patient has been exposed to probenecid or another known transporter inhibitor (verapamil, progesterone, etc) in the three months prior to enrollment
* Patient has a history of renal impairment (creatinine clearance \< 50 ml/min)
* Patient has a history of diabetes and is taking oral sulfonylurea agents
Healthy Volunteers:
True
Sex:
MALE
Minimum Age:
18 Years
Maximum Age:
65 Years
Study:
NCT00610532
Study Brief:
Protocol Section:
NCT00610532