Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 9:22 PM
Ignite Modification Date:
2025-12-24 @ 9:22 PM
NCT ID:
NCT03567304
Eligibility Criteria:
Inclusion Criteria:
* Documented HIV infection
* Age 20 years old and above
* On EFV-based regimen (EFV and 2 Nucleoside Reverse Transcriptase Inhibitors) for at least 1 year prior to enrollment
* CD4 ≥ 200 cell/mm3 and viral load \< 200 copies/mL within 12 months before enrollment
* Able to be read and write in Thai language
* Willing to sign informed consent and able to follow up
* The neurocognitive battery test is compatible with asymptomatic neurocognitive impairment (ANI) or mild neurocognitive disorder (MND) using Frascati's criteria
Exclusion Criteria:
* History of Traumatic Brain Injury, Developmental delay or intellectual deficit, or other neurological conditions have deleterious effects on neurocognitive test based on investigator opinion.
* Active syphilis or on going to treatment with positive for syphilis serological marker (rapid plasma reagin; RPR) in 3 Months before entry study
* Pregnancy
* Renal failure (creatinine clearance \< 30 mL/min)
* Transaminitis in the past 3 months (≥5 UNL) Or Decompensated cirrhosis (child-pugh C)
* Moderate depressive score; Patient Health Questionnaire-9 score ≥ 10)
* Positive for any hepatitis B virus and hepatitis C virus serological marker in 3 Months before entry study
* History of treatment failure or drug resistance to EFV and or RPV
* Not suitable or contraindication for RPV (continue proton pump inhibitor drug)
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
20 Years
Study:
NCT03567304
Study Brief:
Protocol Section:
NCT03567304