Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 9:22 PM
Ignite Modification Date:
2025-12-24 @ 9:22 PM
NCT ID:
NCT03078504
Eligibility Criteria:
Inclusion Criteria:
* Age 18-89
* Acute renal failure or end-stage renal disease necessitating CRRT
* Admitted to the MICU service
* If on vasopressor/inotropic agent, norepinephrine as only intravenous pressor
* If on vasopressor/inotropic agent, at stable pressor dose for at least four hours
* If on IV fluids, stable dose of crystalloids \<= 100cc/hour and is not receiving colloids for 4 hours or more prior to initiation of CRRT
* Mean arterial pressure (MAP) \>= 65
* Arterial catheter present for continuous blood pressure monitoring
* CRRT duration of 48 hours or less using NxStage System One dialysis system
* successfully tolerated CRRT for at least 4 hours without clotting or hemodynamic instability
* no other procedures, blood products transfusion, or additional medication administration are anticipated during the study period
Exclusion Criteria:
* listed for organ transplant
* atrial fibrillation, other irregular heart rhythm, unstable arrhythmia
* need for more than one intravenous vasopressor agent
* intravenous vasopressor/inotropic agent other than norepinephrine (ie dobutamine, dopamine, vasopressin, epinephrine)
* therapeutic anticoagulation being administered
* known acute myocardial infarction as defined by elevated troponin along with a documented clinical diagnosis during current hospitalization
* known acute stroke, intracerebral hemorrhage, intracranial mass effect, or elevated intracranial pressure within the last 30 days.
* dialysis catheter malfunction and unable to maintain target blood flow rate
* fluid removal (ultrafiltration) rate \> 100mL/hour
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Maximum Age:
89 Years
Study:
NCT03078504
Study Brief:
Protocol Section:
NCT03078504