Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 9:18 PM
Ignite Modification Date:
2025-12-24 @ 9:18 PM
NCT ID:
NCT03485404
Eligibility Criteria:
Inclusion Criteria:
* 1\. Age equals or over 65
* 2\. Scheduled for spinal or joint replacement surgery under general anesthesiaļ¼estimated surgery time over 2h.
* 3\. Signed written informed consent obtained
* 4\. Non-surgical Controls are age and sex - matched community elderly residents.
Exclusion Criteria:
* 1\. Disease of the central nervous system that impairs cognitive function, including all kinds of dementia, and depression
* 2\. MMSE score \< 24
* 3\. Received education for less than 5 years
* 4\. Currently taking sedative or antidepressant drugs
* 5\. Has taken vitamin B12, folic acid or their derivatives (methycobalamin, cobalamin, tetrahydrofolic acid, etc.) within 6 months.
* 6\. Has accepted cardiac or neurological surgery within one year.
* 7\. Was admitted for other clinical trials within 3 month
* 8\. Patients that regularly taking drugs that affect vitamin B absorption, including colchicine, neomycin, salicylate.
* 9\. Has severe visual or auditory problems
* 10\. Alcohol or drug dependent (alcohol dependent: drank more than 100 mL of Chinese liqueur with alcohol concentration over 40% everyday for the past 3 months).
* 11\. Patients that are already admitted for this study can not be admitted the second time, no matter the cause of surgery
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
65 Years
Study:
NCT03485404
Study Brief:
Protocol Section:
NCT03485404