Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 9:11 PM
Ignite Modification Date:
2025-12-24 @ 9:11 PM
NCT ID:
NCT02258204
Eligibility Criteria:
Inclusion Criteria:
* Sudden focal neurological deficit attributable to acute ischemic stroke.
* Age between 18 and 85.
* Time from symptom onset less than 4.5 hours.
* NIHSS score between 7 and 20.
* Informed consent for participation.
* Ketamine can be administered within 15 minutes after onset of tPA infusion.
* MRI-based AIS diagnosis.
* Middle cerebral (M1 or M2 segment) and/or distal internal carotid artery occlusion.
* No intracranial hemorrhage on MRI.
* Patient eligible for thrombectomy.
Exclusion Criteria:
* Contraindication to IV tPA treatment.
* Contraindication to ketamine.
* Contraindication to MRI.
* Contraindication to intravascular iodinated contrast media.
* Consciousness level \>1 on question 1a of NIHSS.
* Pre-stroke mRS ≥3.
* Concomitant medical illness that would interfere with outcome assessments and follow-up (e.g. advanced cancer or respiratory disease).
* Previous participation in this trial or current participation in another investigational drug trial.
* Infarct volume on diffusion weighted MRI more than 100 mL.
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Maximum Age:
85 Years
Study:
NCT02258204
Study Brief:
Protocol Section:
NCT02258204