Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 7:58 PM
Ignite Modification Date:
2025-12-24 @ 7:58 PM
NCT ID:
NCT05191004
Eligibility Criteria:
Inclusion Criteria:
1. Men and women with diagnosis of locally advanced inoperable or metastatic HR+HER2- breast cancer
2. Evidence of disease progression on immediate prior therapy as determined by the Investigator per standard criteria
3. Patients must have received standard of care treatments for their breast cancer and be eligible to receive fulvestrant
* Prior standard of care treatments must include treatment with hormonal therapy in combination with an approved CDK4/6 inhibitor
4. Patients must have endocrine-resistant disease
5. Have no known active or symptomatic central nervous system (CNS) disease
6. Eastern Cooperative Oncology Group Performance Status (ECOG PS) ≤ 1
7. Life expectancy of \> 6 months
8. Eligible to receive fulvestrant
9. Adequate bone marrow and organ function
Exclusion Criteria:
1. Have received chemotherapy, hormonal therapy (with the exception of ongoing LHRH analogs in male patients and premenopausal women), radiation, or biological anti-cancer therapy within 14 days prior to the first dose of NUV-422 and fulvestrant
2. Received treatment with an investigational agent for any indication within 14 days for non-myelosuppressive agent or 21 days (of \< 5 half-lives) for myelosuppressive agent prior to first dose of NUV-422 and fulvestrant
3. Moderate liver impairment which would require a reduced dose of fulvestrant
4. Requires medications that are known to be strong inducers and/or inhibitors of CYP3A4/5 enzymes
* For Phase 1b only: requires medications that are known to be moderate inducers and/or inhibitors of CYP3A4/5 enzymes
5. Known allergy or hypersensitivity to fulvestrant
6. For Phase 2 only: prior therapy with fulvestrant and/or investigational ER targeted agent
7. Females who are pregnant or breast feeding
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Study:
NCT05191004
Study Brief:
Protocol Section:
NCT05191004