Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 1:03 PM
Ignite Modification Date:
2025-12-24 @ 1:03 PM
NCT ID:
NCT03478761
Eligibility Criteria:
Inclusion Criteria:
Patients who have undergone genetic testing for a CYP24A1 mutation with at least 3 of the following:
* Urinary Stone Disease
* Nephrocalcinosis
* Metabolic Bone Disease
* Serum Calcium \>/= 9.6 mg/dL
* Parathyroid hormone (PTH) \< 30 pg/mL
* 1,25-dihydroxyvitamin D \> 40 pg/mL OR a family member of a patient who meets the above criteria
Exclusion Criteria:
Patients who have tested negative for a CYP24A1 mutation with an alternative diagnosis that might explain hypercalcemia/hypercalciuria/stone disease:
* Sarcoidosis
* Lymphoma
* Tuberculosis
* Fungal infections
* Excessive exogenous calcium or vitamin D intake
Healthy Volunteers:
False
Sex:
ALL
Study:
NCT03478761
Study Brief:
Protocol Section:
NCT03478761